Very prolonged liposomal amphotericin B use leading to a lysosomal storage disease
| Autor: | Elina Teicher, G. Maigne, E. Fourn, Olivier Lambotte, Cedric Aumont, Jean-Marie Michot, Catherine Guettier, Jean-François Delfraissy, C. Gubavu, A. Coilly, Olivier Lortholary, Mylène Sebagh, Adela Angoulvant, Stéphane Blanche, Jean-Charles Duclos-Vallée |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Microbiology (medical) Pathology medicine.medical_specialty Antifungal Agents Biopsy Hepatosplenomegaly Antifungal drug Granulomatous Disease Chronic Aspergillosis Chronic granulomatous disease Amphotericin B Lysosomal storage disease medicine Humans Pharmacology (medical) Neuroaspergillosis Histocytochemistry business.industry General Medicine medicine.disease Pancytopenia Lysosomal Storage Diseases Infectious Diseases Liver medicine.symptom business Nodular regenerative hyperplasia medicine.drug |
| Zdroj: | International Journal of Antimicrobial Agents. 43:566-569 |
| ISSN: | 0924-8579 |
| Popis: | Amphotericin B is a powerful polyene antifungal drug used for treating systemic fungal infections and is usually administered for a short period. Side effects after prolonged use are unknown in humans. Here we report the case of a 28-year-old man suffering from chronic granulomatous disease (CGD), treated for invasive cerebral aspergillosis with liposomal amphotericin B (L-AmB) for a very long time (8 consecutive years). We describe the efficacy and safety of this treatment in the long term. Aspergillosis was kept under control as long as L-AmB therapy was maintained, but relapsed when the dose was reduced. No overt renal toxicity was noted. The patient gradually developed hepatosplenomegaly and pancytopenia. Abnormalities of bone marrow were similar to the sea-blue histiocyte syndrome. Liver biopsy showed images of nodular regenerative hyperplasia related to CGD as well as a histiocytic storage disease. We discuss the very prolonged use of L-AmB leading to the development of a lysosomal storage disease. |
| Databáze: | OpenAIRE |
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