Pathways of phosphatidylcholine biosynthesis in rat liver
| Autor: | F.D. Collins, M.A. Trewhella |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
Acylation Biophysics Arachidonic Acids Palmitic Acids Biology Cytosine Nucleotides Tritium Biochemistry Methylation Models Biological Phosphatidylcholine Biosynthesis Choline Phosphates chemistry.chemical_compound Structure-Activity Relationship Endocrinology Cytosine nucleotide Phosphatidylcholine Animals Phosphatidylethanolamine Carbon Isotopes Phosphatidylethanolamines Fatty Acids Phosphorus Isotopes Cytidine Rats chemistry Linoleic Acids Liver Ethanolamines Phosphatidylcholines lipids (amino acids peptides and proteins) Stearic Acids |
| Zdroj: | Biochimica et biophysica acta. 296(1) |
| ISSN: | 0006-3002 |
| Popis: | 1. 1. The specific radioactivities of individual molecular species of phosphatidylcholine and phosphatidylethanolamine have been determined in rat liver after the administration of [32P]orthophosphate, [Me-3H]chorine chloride and 2-amino-[2-14C]-ethanol 1 h before death. 2. 2. An estimate of the extent of the methylation of phosphatidylethanolamine to yield phosphatidylcholine for different molecular species suggests that 1-stearoyl-2-arachidonoyl phosphatidylcholine is formed largely via the methylation pathway while 1-palmitoyl-2-linoleoyl phosphatidylcholine is formed mainly via cytidine diphosphocholine. 3. 3. It is concluded that acylation reactions are important for the incorporation of stearic and arachidonic acids while direct exchange with free choline is a relatively minor pathway. |
| Databáze: | OpenAIRE |
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