Application of QCM in Peptide and Protein-Based Drug Product Development
| Autor: | Tomasz Wasilewski, Dorian Migoń, Dariusz Suchy |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Pharmaceutical Science Nanotechnology Peptide 02 engineering and technology Review Biosensing Techniques sensors Analytical Chemistry protein aggregation Crystal lcsh:QD241-441 03 medical and health sciences Resonator quartz crystal microbalance lcsh:Organic chemistry Drug Development Drug Discovery Physical and Theoretical Chemistry Quartz 030304 developmental biology chemistry.chemical_classification 0303 health sciences business.industry Organic Chemistry Proteins Quartz crystal microbalance 021001 nanoscience & nanotechnology biosensors AT-cut crystals chemistry Pharmaceutical Preparations Chemistry (miscellaneous) New product development Quartz Crystal Microbalance Techniques Molecular Medicine Drug product peptide aggregation protein formulation 0210 nano-technology business Peptides Biosensor |
| Zdroj: | Molecules Molecules, Vol 25, Iss 3950, p 3950 (2020) |
| ISSN: | 1420-3049 |
| Popis: | AT-cut quartz crystals vibrating in the thickness-shear mode (TSM), especially quartz crystal resonators (QCRs), are well known as very efficient mass sensitive systems because of their sensitivity, accuracy, and biofunctionalization capacity. They are highly reliable in the measurement of the mass of deposited samples, in both gas and liquid matrices. Moreover, they offer real-time monitoring, as well as relatively low production and operation costs. These features make mass sensitive systems applicable in a wide range of different applications, including studies on protein and peptide primary packaging, formulation, and drug product manufacturing process development. This review summarizes the information on some particular implementations of quartz crystal microbalance (QCM) instruments in protein and peptide drug product development as well as their future prospects. |
| Databáze: | OpenAIRE |
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