Comparison of the apparent antidepressant activity of (−) and (+) tranylcypromine in an animal model
| Autor: | Norton H. Neff, Marvin A. Oleshansky, Jose A. Fuentes |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
Drug Monoamine Oxidase Inhibitors Reserpine Time Factors Monoamine oxidase media_common.quotation_subject Motor Activity Pharmacology Models Biological Biochemistry Isomerism In vivo medicine Animals media_common Brain Chemistry Chemistry Tranylcypromine Substrate (chemistry) Antidepressive Agents In vitro Rats Antidepressant Amine gas treating medicine.drug |
| Zdroj: | Biochemical Pharmacology. 25:801-804 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/0006-2952(76)90150-7 |
| Popis: | The isomers of tranylcypromine (TCP) readily entered the rat brain after intraperitoneal administration and reached peak concentrations within 15 min. Apparently, (−) TCP entered the brain more rapidly and reached somewhat higher concentrations than (+) TCP. Alter a dose of 2.5 mg/kg of (−) or (+) TCP. there was significantly more drug in brain than has been reported necessary to block the re-uptake of amines by synaptosomes. Both isomers blocked monoamine oxidase in vivo and in vitro. (+) TCP was between 10 and 60 times more active than (−) TCP, depending on the amine substrate evaluated, and both isomers were better inhibitors of type-B monoamine oxidase activity than type-A activity. The (+) isomer was more active in preventing reserpine-induced sedation in the rat than the (−) isomer. The ability to prevent the rescrpine syndrome was apparently related to the ability of the drugs to block monoamine oxidase activity rather than to blockade of amine re-uptake. |
| Databáze: | OpenAIRE |
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