Ribosome-Associated ncRNAs (rancRNAs) Adjust Translation and Shape Proteomes

Autor:	Pecoraro, Valentina, Rosina, Alessia, Polacek, Norbert
Rok vydání:	2022
Předmět:	540 Chemistry Genetics 570 Life sciences biology Molecular Biology Biochemistry
Zdroj:	Pecoraro, Valentina; Rosina, Alessia; Polacek, Norbert (2022). Ribosome-Associated ncRNAs (rancRNAs) Adjust Translation and Shape Proteomes. Non-Coding RNA, 8(2), p. 22. MDPI 10.3390/ncrna8020022
ISSN:	2311-553X
Popis:	The regulation of protein synthesis is of extreme importance for cell survival in challenging environmental conditions. Modulating gene expression at the level of translation allows a swift and low-energy-cost response to external stimuli. In the last decade, an emerging class of regulatory ncRNAs, namely ribosome-associated non-coding RNAs (rancRNAs), has been discovered. These rancRNAs have proven to be efficient players in the regulation of translation as a first wave of stress adaptation by directly targeting the ribosome, the central enzyme of protein production. This underlying principle appears to be highly conserved, since rancRNAs are present in all three domains of life. Here, we review the major findings and mechanistic peculiarities of rancRNAs, a class of transcripts that is providing new and broader perspectives on the complexity of the ribosome and translation regulation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a600d5f86577ee4c35f75cc5219f566a https://pubmed.ncbi.nlm.nih.gov/35314615 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.