Effect of Maternal Tobacco Smoke Exposure on the Placental Transcriptome
| Autor: | A. Milcova, Anna Pastorkova, Alzbeta Vasikova, Jan Topinka, Radim J. Sram, Ivan Balascak, Radim Brdicka, Michaela Dostalova Merkerova, Hana Bruchova |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Placenta CYP1B1 Biology Tobacco smoke Cohort Studies Andrology Transcriptome Pregnancy Gene expression medicine Humans RNA Messenger Gene Oligonucleotide Array Sequence Analysis Genetics Microarray analysis techniques Gene Expression Profiling Smoking Infant Newborn Obstetrics and Gynecology Gene expression profiling medicine.anatomical_structure Reproductive Medicine Prenatal Exposure Delayed Effects Female Developmental Biology |
| Zdroj: | Placenta. 31:186-191 |
| ISSN: | 0143-4004 |
| Popis: | Smoking in pregnancy increases a woman's risk of preterm delivery resulting in serious neonatal health problems and chronic lifelong disabilities for the children (e.g., mental retardation, learning problems). To study the effects of tobacco smoke on the placental transcriptome, we performed gene expression profiling on placentas from women exposed to tobacco smoke in pregnancy (N = 12) and from those without significant exposure (N = 64). Gene expression profiles were determined by Illumina HumanRef-8 v2 Expression BeadChips with 18,216 gene probes. Microarray data were normalized by quantile method and filtered for a detection P-value |
| Databáze: | OpenAIRE |
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