Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC
| Autor: | Sérgio Luís Dalmora, Lisiane Bajerski, Thiago Barth, Simone Gonçalves Cardoso, Isabel Fração Diefenbach, Maximiliano da Silva Sangoi |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Chromatography
high performance liquid chromatography Chemistry Capillary action Sodium chemistry.chemical_element General Chemistry Electrolyte High-performance liquid chromatography Cetirizine dihydrochloride Cetirizine lcsh:Chemistry Electrophoresis Capillary electrophoresis lcsh:QD1-999 medicine capillary eletrophoresis cetirizine medicine.drug |
| Zdroj: | Química Nova v.33 n.1 2010 Química Nova Sociedade Brasileira de Química (SBQ) instacron:SBQ Química Nova, Vol 33, Iss 1, Pp 114-118 (2010) Química Nova, Volume: 33, Issue: 1, Pages: 114-118, Published: 2010 |
| Popis: | A capillary electrophoresis (CE) method was developed and validated for determination of cetirizine dihydrochloride in tablets and compounded capsules. The electrophoretic separation was performed in an uncoated fused-silica capillary (40 cm x 50 μm i.d.) using 20 mmol L-1 sodium tetraborate buffer (pH 9.3) as background electrolyte, a hydrodinamic sample injection at 50 mBar for 5 s, 20 KV applied voltage at 25 °C, and detection at 232 nm. The proposed method was compared with the high performance liquid chromatographic (HPLC) method previously validated for this drug, and statistical analysis showed no significant difference between the techniques. |
| Databáze: | OpenAIRE |
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