Effects of 5-HT(1B) receptor ligands microinjected into the accumbal shell or core on the sensitization to cocaine in rats
| Autor: | Edmund Przegaliński, Iwona Papla, Joanna Siwanowicz, Małgorzata Filip |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Agonist
Male Microinjections medicine.drug_class Pyridines Pharmacology Nucleus accumbens Motor Activity Nucleus Accumbens Cocaine medicine Animals Pharmacology (medical) Drug Interactions Pyrroles Rats Wistar Receptor Biological Psychiatry 5-HT receptor Sensitization CP-93129 Analysis of Variance Dose-Response Relationship Drug Chemistry Antagonist Rats Serotonin Receptor Agonists Psychiatry and Mental health medicine.anatomical_structure Neurology Receptors Serotonin Benzamides Receptor Serotonin 5-HT1B Neurology (clinical) Serotonin Serotonin Antagonists |
| Zdroj: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 12(5) |
| ISSN: | 0924-977X |
| Popis: | The present study was designed to find out whether 5-HT(1B) receptors located in subareas of the nucleus accumbens played a role in cocaine sensitization in rats, and whether pharmacological activation of these receptors could modify this drug effect. Male Wistar rats implanted bilaterally with cannulae into the accumbens shell or core were microinjected with GR 55562 (an antagonist of 5-HT(1B) receptors) or CP 93129 (an agonist of 5-HT(1B) receptors). The rats, which were repeatedly (for 5 days) administered with cocaine (10 mg/kg) and then challenged with cocaine (10 mg/kg) after 5-day withdrawal period, showed significantly higher locomotor hyperactivity in comparison with the effect observed in saline-pretreated and cocaine challenged rats. GR 55562 (0.1-10 microg/side), administered for 5 days into the accumbens shell, but not into the core, prior to cocaine dose-dependently attenuated cocaine sensitization. When injected for 5 days into either the accumbens shell or core before cocaine, CP 93129 (0.1-10 microg/side) had no effect on the development of cocaine sensitization. To examine the effects of GR 55562 and CP 93129 on the expression of cocaine sensitization, the drugs were given acutely before a challenge dose of cocaine (10 mg/kg) on day 10. No change in cocaine sensitization was observed after injection of GR 55562 (0.1-10 microg/side) to the either accumbens subregion or after injection of CP 93129 (0.1-10 microg/side) into the core. However, an intra-accumbens shell injection of CP 93129 (10-30 microg/side) increased sensitization to cocaine, and this enhancement was attenuated after local injection of GR 55562 (1 microg/side). Our findings indicate that behavioral sensitization to cocaine may be modulated by 5-HT(1B) receptor ligands in the accumbens shell, but not into the core. They suggest that the inhibition of 5-HT(1B) receptors in the accumbens shell attenuates the development, whereas their pharmacological activation enhances the expression of cocaine sensitization. |
| Databáze: | OpenAIRE |
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