Impact of Interatrial Communication on Left Ventricle Performance in Patients with Significant Post-tricuspid Shunt

Autor: Milad El-Segaier, Mohammed Omar Galal, Abdulrahman Almoukirish, Abdalla Saeed, Motea E. Elhoury
Rok vydání: 2015
Předmět:
Heart Septal Defects
Ventricular
Male
medicine.medical_specialty
medicine.drug_class
Heart Ventricles
Medizin
Diastole
030204 cardiovascular system & hematology
Doppler echocardiography
03 medical and health sciences
0302 clinical medicine
Internal medicine
Mitral valve
Natriuretic Peptide
Brain
medicine
Natriuretic peptide
Humans
030212 general & internal medicine
Ductus Arteriosus
Patent
Mitral regurgitation
Tricuspid valve
medicine.diagnostic_test
business.industry
Infant
Mitral Valve Insufficiency
Myocardial Contraction
Echocardiography
Doppler
Peptide Fragments
Cardiac surgery
medicine.anatomical_structure
ROC Curve
Ventricle
Child
Preschool
Pediatrics
Perinatology and Child Health
Cardiology
Mitral Valve
Female
Tricuspid Valve
Cardiology and Cardiovascular Medicine
business
Biomarkers
Zdroj: Pediatric cardiology. 37(3)
ISSN: 1432-1971
Popis: Infants with post-tricuspid valve shunts (PTS) may benefit from interatrial communication (IAC). The effect of IAC on left ventricular (LV) performance in these patients was studied. IAC was documented prospectively in 55 patients with PTS. Clinical status, echocardiographic dimensions of LV, mitral inflow Doppler, tissue Doppler velocities and time intervals were measured. Creatinine kinase (CK), CKMB, troponin-I and NT pro-brain natriuretic peptide (NT pro-BNP) were measured. Patients were divided into four groups: (A) PTS but no IAC (n = 32); (B) PTS and IAC (n = 23); (C) VSD but no IAC (n = 16); and (D) VSD and IAC (n = 19). Group A had more frequent mitral regurgitation (p = 0.041), larger mitral annulus (1.80 vs. 1.30 cm, p < 0.0001) and larger LV systolic and diastolic dimensions (2.01 vs. 1.40 and 3.28 vs. 2.35 cm, p < 0.001) than group B. The E-wave deceleration time tended to be longer in group A (121.0 vs. 106.8 ms, p = 0.06). By tissue Doppler, group A had E'- and S-waves significantly taller (15.51 vs. 13.14 and 7.69 vs. 6.72 cm, p = 0.04 and p = 0.005, respectively) than group B. Also, NT pro-BNP was significantly higher in group A (1116.15 vs. 458.73 pg/ml, p = 0.028). Group C had significant larger mitral z-score values (1.2 vs. 0.01, p < 0.001), larger LV diameter z-score (p = 0.001) and higher NT pro-BNP level (1477.37 vs. 451.66 pg/ml, p = 0.001) than group D. There was no significant difference in the clinical status between the groups. In children with PTS, the presence of IAC could be beneficial. Their echocardiographic parameters and biomarker show better systolic and diastolic LV performance.
Databáze: OpenAIRE
Externí odkaz: