How should we describe the radioblologic effect of extracranial stereotactic radlosurgery: equivalent uniform dose or tumor control probability?
| Autor: | Francis Newman, Stanley H Benedict, Tracey E. Schefter, Laurie E. Gaspar, Steve McCourt, Qiuwen Wu, Brian D. Kavanagh, Kelly Stuhr, Robert Timmerman, R. M. Cardinale |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Post hoc Cell Survival medicine.medical_treatment Radiosurgery Radiation Tolerance Sensitivity and Specificity Radiation tolerance Clinical investigation Medicine Dosimetry Humans Radiometry business.industry Brain Neoplasms Radiotherapy Planning Computer-Assisted Brain Radiotherapy Dosage General Medicine Equivalent uniform dose Tumor control Radiation therapy Treatment Outcome Radiology business Nuclear medicine |
| Zdroj: | Medical physics. 30(3) |
| ISSN: | 0094-2405 |
| Popis: | Extracranial stereotactic radiosurgery (ESR) is now undergoing clinical investigation at numerous institutions as a treatment for solitary malignant lesions. Because there is no standard ESR technique, the same minimum dose might be applied through widely variable target dose-volume histograms. For multicenter trials of ESR or interinstitutional comparisons, a reliable index of radiobiological dose equivalency might facilitate the evaluation of dose-response relationships. Equivalent uniform dose (EUD) and tumor control probability (TCP) were considered for this application. While EUD appears more robust for the prospective description of ESR, TCP is expected to remain more valuable for a post hoc estimation of radiosensitivity parameters. |
| Databáze: | OpenAIRE |
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