Red cell exchange transfusions increase cerebral capillary transit times and may alter oxygen extraction in sickle cell disease

Autor: Tonner DeBeer, Lori C. Jordan, Spencer Waddle, Chelsea Lee, Niral J. Patel, Maria Garza, Taylor Davis, Sumit Pruthi, Sky Jones, Manus J. Donahue
Rok vydání: 2022
Předmět:
Zdroj: NMR in Biomedicine. 36
ISSN: 1099-1492
0952-3480
Popis: Persons with sickle cell disease (SCD) suffer from chronic hemolytic anemia, reduced blood oxygen content, and lifelong risk of silent and overt stroke. Major conventional stroke risk factors are absent in most individuals with SCD, yet nearly 50% have evidence of brain infarcts by the age of 30 years, indicating alternative etiologies for ischemia. We investigated whether radiological evidence of accelerated blood water transit through capillaries, visible on arterial spin labeling (ASL) magnetic resonance imaging, reduces following transfusion-induced increases in hemoglobin and relates to oxygen extraction fraction (OEF). Neurological evaluation along with anatomical and hemodynamic imaging with cerebral blood flow (CBF)-weighted pseudocontinuous ASL and OEF imaging with T
Databáze: OpenAIRE
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