Metabolism and utilisation of short chain fatty acids produced by colonic fermentation
| Autor: | C. Morand, C. Demigne, Christian Rémésy |
|---|---|
| Přispěvatelé: | ProdInra, Migration, Unité de recherche Maladies Métaboliques et Micronutriments (U3M), Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 1992 |
| Předmět: |
chemistry.chemical_classification
0303 health sciences Isovalerate 030309 nutrition & dietetics Chemistry Bicarbonate [SDV]Life Sciences [q-bio] digestive oral and skin physiology Short-chain fatty acid Metabolism Pyruvate carboxylase Amino acid Butyric acid [SDV] Life Sciences [q-bio] 03 medical and health sciences chemistry.chemical_compound medicine.anatomical_structure Biochemistry medicine Large intestine ComputingMilieux_MISCELLANEOUS 030304 developmental biology |
| Zdroj: | ILSI Human Nutrition Reviews Workshop Workshop, Apr 1991, Bruxelles, Belgium Dietary Fibre — A Component of Food ISBN: 9781447119302 |
| Popis: | Most of the carbohydrates of the fibre fraction are extensively broken down by the microflora when they reach the large intestine; this metabolic process results in the production of gas and short chain fatty acids (SCFA; essentially acetic, propionic and butyric acids). In non-ruminant mammals, including humans, the large intestine is the major site of SCFA production and they are extensively absorbed. The mechanisms for SCFA absorption depend on conditions prevailing in the intestinal lumen; basically, the SCFA always diffuse along the concentration gradient, mainly the non-ionised (protonated) form. However, SCFA absorption may involve facilitated transfers: when the lumen pH is close to neutral, SCFA absorption is parallel to a net secretion of bicarbonate (Hoverstad, 1986). This process contributes to water and mineral recovery from the large intestine. Absorption capacity from the human colon has been estimated at 200 to 700 mmol/24 hours (Cummings, 1984), which is in accordance with an estimated breakdown of 30 to 60 g carbohydrates in the colon. There is also a minor production of some other SCFA (isobutyrate, n-valerate, isovalerate), the iso C4 and C5 monocarboxylates chiefly arise from the de-amination of branched chain amino acids. |
| Databáze: | OpenAIRE |
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