Stem cell therapy: a new approach to the treatment of refractory depression

Autor: Takao Ishii, Wataru Ukai, Hanako Tsujino, Tomohiro Shirasaka, Kengo Furuse, Eri Hashimoto, Toshikazu Saito, Yoshiyasu Kigawa
Jazyk: angličtina
Rok vydání: 2014
Předmět:
medicine.medical_specialty
Refractory depression
Interneuron
medicine.medical_treatment
Translational Neurosciences - Original Article
Clinical Neurology
Hippocampus
Antidepressant
Depressive Disorder
Treatment-Resistant
Neural Stem Cells
Internal medicine
Sertraline
medicine
Animals
GABAergic Neurons
Rats
Wistar
Parvalbumin positive interneuron
PSD-95
Biological Psychiatry
Stem cell therapy
biology
Intracellular Signaling Peptides and Proteins
Brain
Membrane Proteins
Stem-cell therapy
Combined Modality Therapy
Neural stem cell
Antidepressive Agents
Psychiatry and Mental health
Fetal alcohol spectrum disorder
Disease Models
Animal
Endocrinology
medicine.anatomical_structure
Parvalbumins
Neurology
nervous system
biology.protein
GABAergic
Neurology (clinical)
Stem cell
Psychology
Disks Large Homolog 4 Protein
Parvalbumin
Stem Cell Transplantation
Zdroj: Journal of Neural Transmission
ISSN: 1435-1463
0300-9564
Popis: To better understand the relationship of repeated exposure to adversity during early development as a risk factor for refractory depression, we exposed pregnant female rats to ethanol and the resulting pups to corticosterone during adolescence. A stressful forced swim test was then used to induce depression-like behavior. The adolescent rat brains were examined for the possible therapeutic benefit of a combination of sertraline, an antidepressant, and neural stem cells (NSCs) complexed with atelocollagen in relation to the level of GABAergic interneuron and synaptic protein density in different brain regions. The combined exposures of prenatal and adolescent stress resulted in a reduction in parvalbumin (PV)-positive phenotype of GABAergic interneurons and reduced postsynaptic density protein 95 (PSD-95) levels in the anterior cingulate cortex, amygdala, and hippocampus. Treatments with sertraline and NSCs reversed the reductions in PV-positive cells and PSD-95 levels. Furthermore, the combined treatment of sertraline and NSCs resulted in reduced depressive-like behaviors. These experiments underscore a potentially important role for synaptic remodeling and GABAergic interneuron genesis in the treatment of refractory depression and highlight the therapeutic potential of stem cell and pharmacological combination treatments for refractory depression.
Databáze: OpenAIRE
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