Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1
| Autor: | Huda Y. Zoghbi, Christina Thaller, Matthew F. Rose, Kaashif A. Ahmad |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Cerebellum
medicine.medical_specialty Auditory Pathways Corticotropin-Releasing Hormone Nerve net Glutamic Acid Mice Transgenic Hindbrain Biology Nitric Oxide Arousal Levodopa Mice chemistry.chemical_compound Pregnancy Internal medicine Neural Pathways Basic Helix-Loop-Helix Transcription Factors medicine Animals Neurotransmitter Neurons Multidisciplinary Glutamate receptor Gene Expression Regulation Developmental Biological Sciences Proprioception Acetylcholine Rhombencephalon medicine.anatomical_structure Endocrinology chemistry Dorsal column nuclei Auditory Perception Excitatory postsynaptic potential Female Nerve Net Somatostatin Neuroscience |
| Zdroj: | Proceedings of the National Academy of Sciences. 106:22462-22467 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | Hindbrain networks important for sensation and arousal contain diverse neuronal populations with distinct projections, yet share specific characteristics such as neurotransmitter expression. The relationship between the function of these neurons, their developmental origin, and the timing of their migration remains unclear. Mice lacking the proneural transcription factor Math1 ( Atoh1 ) lose neurons essential for hearing, balance, and unconscious proprioception. By using a new, inducible Math1 Cre * PR allele, we found that Math1 is also required for the conscious proprioceptive system, including excitatory projection neurons of the dorsal column nuclei and for vital components of the interoceptive system, such as Barrington's nucleus, that is closely associated with arousal. In addition to specific networks, Math1 lineages shared specific neurotransmitter expression, including glutamate, acetylcholine, somatostatin, corticotropin releasing hormone, and nitric oxide. These findings identify twenty novel Math1 lineages and indicate that the Math1 network functions partly as an interface for conscious (early-born) and unconscious (late-born) proprioceptive inputs to the cortex and cerebellum, respectively. In addition, these data provide previously unsuspected genetic and developmental links between proprioception, interoception, hearing, and arousal. |
| Databáze: | OpenAIRE |
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