The Effect of Stool Transplantation on Weight Control in Obese Rats
| Autor: | Cynthia Fontoura Klas, Camila Aparecida Moraes Marques, Kader Osman, Luiz Felipe Paludo Carmona, Rebeca Loureiro Rebouças, Luiz Fernando Kubrusly, Géssica de Mattos Diosti |
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| Rok vydání: | 2021 |
| Předmět: |
obesidade
obesity medicine.medical_specialty Normal diet Adipose tissue Cafeteria stool transplantation Gastroenterology transplante de fezes 03 medical and health sciences 0302 clinical medicine Internal medicine microbiota medicine 030304 developmental biology 0303 health sciences biology business.industry biology.organism_classification medicine.disease Obesity Small intestine ratos Wistar Wistar rats Transplantation medicine.anatomical_structure 030211 gastroenterology & hepatology Metabolic syndrome medicine.symptom business Weight gain |
| Zdroj: | Journal of Coloproctology (Rio de Janeiro) v.41 n.1 2021 Journal of Coloproctology (Rio de Janeiro. Online) Sociedade Brasileira de Coloproctologia (SBCP) instacron:SBCP Journal of Coloproctology (Rio de Janeiro), Volume: 41, Issue: 1, Pages: 58-62, Published: 16 JUL 2021 |
| ISSN: | 2317-6423 2237-9363 |
| DOI: | 10.1055/s-0041-1724068 |
| Popis: | Introduction Obesity is defined as a multifactorial metabolic syndrome in which there is an excessive number of fat cells within the tissues. It is discussed that intestinal microbiota might have a relevant relation with obesity, since it is relevantly altered in obese patients. Objectives To assess the effect of stool transplantation (ST) in the condition of obesity and its outcomes in an experimental model of cafeteria diet by analyzing histology and weight gain. Methods Forty male Wistar rats were randomly assigned to 5 groups: control (CO), control with antibiotics (CO+ATB), obesity (CAF+ATB), stool transplantation (ATB+ ST) and obesity with stool transplantation (CAF+ATB+ST). During the experiment, obesity induction groups received cafeteria diet, whereas the remaining groups had normal diet ad libitum. After 3 months, daily ST was carried out for 8 weeks by gavage procedure. The animals were euthanized, and the small intestine was harvested for further analysis. Results It was observed that before starting the ST, the cafeteria and normal diet groups had significant weight difference (p |
| Databáze: | OpenAIRE |
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