Blood contamination of the pharmaceutical staff by irinotecan and its two major metabolites inside and outside a compounding unit
| Autor: | Stéphanie Lagadu, Victoire Béchet, Raphaël Delépée, Frédéric Beau, Fabienne Divanon, H Benoist, François Sichel, Guillaume Saint-Lorant |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Drug Compounding Blood contamination Antineoplastic drug Antineoplastic Agents Pharmacy Irinotecan 03 medical and health sciences 0302 clinical medicine Tandem Mass Spectrometry Adverse health effect Occupational Exposure medicine Humans Pharmacology (medical) Intensive care medicine business.industry Contamination 030210 environmental & occupational health Pharmaceutical Preparations Oncology Compounding 030220 oncology & carcinogenesis Healthcare settings Antineoplastic Drugs Drug Contamination business Environmental Monitoring medicine.drug |
| Zdroj: | Journal of Oncology Pharmacy Practice. 28:777-784 |
| ISSN: | 1477-092X 1078-1552 |
| Popis: | Background Caregivers in healthcare settings are exposed to a risk of antineoplastic drug contamination which can lead to adverse health effects. Biological monitoring is necessary to estimate the actual level of exposure of these workers. This study was conducted with the aim of assessing blood contamination levels by irinotecan and its metabolites of pharmaceutical staff operating inside and outside a compounding unit. Methods The study took place within the pharmaceutical unit of a French comprehensive cancer centre. Blood samples were collected from the pharmacy workers operating inside and outside the compounding unit, and analysed by UHPLC-MS/MS. Plasma and red blood cell irinotecan and its metabolites (SN-38; APC) were determined with a validated analytical method detection test. Results A total of 17/78 (21.8%) plasma and red blood cell-based assays were found to be contaminated among staff. Overall, the total number of positive assays was significantly higher for staff members working outside the compounding unit than for workers working inside it ( P = 0.022), with respectively 5/42 (11.9%) and 12/36 (33.3%) positive assays. For plasma dosages, the “outside” group had a significantly higher number of positive assays ( P = 0.014). For red blood cell-based assays, no significant difference was found ( P = 0.309). Conclusions This study reveals that pharmaceutical staff serving in health care settings are exposed to a risk of antineoplastic drug contamination, not only inside the compounding room but also in adjacent rooms. The results would help to raise awareness and potentially establish protective measures for caregivers working in areas close to the compounding room as well. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|