Design of a small animal MR compatible PET scanner
| Autor: | M. Dahlborn, A. Boutefnouchet, Yiping Shao, R. Slates, Simon R. Cherry, Keyvan Farahani |
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| Rok vydání: | 1999 |
| Předmět: |
Nuclear and High Energy Physics
Photomultiplier Scanner Materials science Optical fiber business.industry Monte Carlo method Resolution (electron density) Image processing Field of view law.invention Optics Nuclear magnetic resonance Nuclear Energy and Engineering law Electrical and Electronic Engineering business Image resolution |
| Zdroj: | IEEE Transactions on Nuclear Science. 46:565-570 |
| ISSN: | 1558-1578 0018-9499 |
| DOI: | 10.1109/23.775580 |
| Popis: | Using a combination of Monte Carlo simulations and experimental measurements we have designed a small-animal MRI-compatible PET (McPET) scanner for simultaneous PET imaging and MRI of mice and rats in vivo. The scanner consists of one ring of 480 LSO (Lu/sub 2/SiO/sub 5/) crystals arranged in three layers, with 160 crystals per layer. The crystal dimensions are 2/spl times/3/spl times/7.5 mm/sup 3/. This was based on a target resolution of 215 mm and simulations showing that a depth of 7.5 mm avoided significant depth-of-interaction effects across the desired field of view. The system diameter of 11.2 cm is large enough to accommodate the animal positioned inside a stereotactic frame. Each crystal is coupled through 2-mm diameter optical fibers to multi-channel photomultiplier tubes which reside outside the main magnetic field. Through 50 cm of optical fiber, a photopeak is clearly seen and the measured energy resolution is 25%. Prototype optical fiber connectors have been tested to increase the flexibility of the system and result in a light loss of only 6%. The proposed system has adequate resolution and sensitivity for a number of applications with small animals and is the first practical device for simultaneous in-vivo imaging with PET and MRI. |
| Databáze: | OpenAIRE |
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