Brain activation during implicit sequence learning in individuals with trichotillomania
| Autor: | Christopher I. Wright, Katherine McMullin, Andrea L. Gold, Nancy J. Keuthen, Brian Martis, Scott L. Rauch, Cary R. Savage, Michelle M. Wedig |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Serial reaction time Obsessive-Compulsive Disorder Impulse control disorder Neuroscience (miscellaneous) Hippocampal formation Hippocampus Severity of Illness Index Trichotillomania mental disorders Basal ganglia Reaction Time medicine Humans Learning Radiology Nuclear Medicine and imaging Brain medicine.disease Magnetic Resonance Imaging Corpus Striatum Implicit learning Functional imaging Psychiatry and Mental health nervous system Female Sequence learning Psychology Neuroscience psychological phenomena and processes Anxiety disorder |
| Zdroj: | Psychiatry Research: Neuroimaging. 154:233-240 |
| ISSN: | 0925-4927 |
| DOI: | 10.1016/j.pscychresns.2006.09.002 |
| Popis: | Trichotillomania (TTM) may be related to obsessive-compulsive disorder (OCD) and other neuropsychiatric conditions characterized by cortico-striatal dysfunction. Functional imaging studies of OCD using an implicit learning task have found abnormalities in striatal and hippocampal activation. The current study investigated whether similar abnormalities occur in TTM. Functional MRI and the serial reaction time (SRT) task were used to assess striatal and hippocampal activation during implicit sequence learning in TTM and healthy control (HC) subjects. The results for 20 age- and education-matched participants (10 TTM, 10 HC) are reported. In comparison with HC participants, those with TTM exhibited no significant differences in implicit learning, or in activation within the striatum, hippocampus, or other brain regions. The current findings do not provide evidence for cortico-striatal dysfunction in TTM. Future studies directly comparing OCD and TTM subjects are warranted to confirm the specificity of abnormal striatal and hippocampal findings during implicit sequence learning in OCD. |
| Databáze: | OpenAIRE |
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