Aggressive Squamous Cell Carcinoma in Organ Transplant Recipients
| Autor: | Carlos Ferrándiz, Vanessa Van-De-Velde, Catherine A. Harwood, Koen D. Quint, Joana Lanz, Marlies Westhuis, Roel E. Genders, Domenic D.G. Vital, Charlotte M. Proby, Véronique Del Marmol, Jürg Hafner, Günther F.L. Hofbauer, Shaaira Nasir, Jan Nico Bouwes Bavinck, Giulia Forchetti |
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| Přispěvatelé: | University of Zurich, Lanz, Joana |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Population Perineural invasion 610 Medicine & health 10045 Clinic for Otorhinolaryngology Dermatology Risk Assessment Gastroenterology Organ transplantation Metastasis 2708 Dermatology Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Prevalence Carcinoma Humans Medicine education Aged Neoplasm Staging Retrospective Studies Original Investigation education.field_of_study business.industry 10177 Dermatology Clinic Retrospective cohort study Organ Transplantation Middle Aged Prognosis medicine.disease Transplant Recipients Europe Survival Rate Transplantation 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Body region business |
| Zdroj: | JAMA Dermatology r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname JAMA Dermatology, 155(1), 66-71 |
| ISSN: | 2168-6084 |
| Popis: | IMPORTANCE Squamous cell carcinoma (SCC) is the most frequent malignant neoplasm found in solid organ transplant recipients and is associated with a more aggressive disease course and higher risk of metastasis and death than in the general population. OBJECTIVES To report the clinicopathologic features of and identify factors associated with aggressive SCC in solid organ transplant recipients. METHODS This retrospective multicentric case series included 51 patients who underwent solid organ transplantation and were found to have aggressive SCC, defined by nodal or distant metastasis or death by local progression of primary SCC. Standard questionnaires were completed by the researchers between July 18, 2005, and January 1, 2015. Data were analyzed between February 22, 2016, and July 12, 2016. RESULTS Of the 51 participants, 43 were men and 8 were women, with a median age of 51 years (range, 19-71 years) at time of transplantation and 62 years (range, 36-77 years) at time of diagnosis of aggressive SCC. The distribution of aggressive SCC was preferentially on the face (34 [67%]) and scalp (6 [12%]), followed by the upper extremities (6 [12%]). A total of 21 tumors (41%) were poorly differentiated, with a median tumor diameter of 18.0 mm (range, 4.0-64.0 mm) and median tumor depth of 6.2 mm (range, 1.0-20.0 mm). Perineural invasion was present in 20 patients (39%), while 23 (45%) showed a local recurrence. The 5-year overall survival rate was 23%, while 5-year disease-specific survival was 30.5%. CONCLUSIONS AND RELEVANCE Results of this case series suggest that anatomical site, differentiation, tumor diameter, tumor depth, and perineural invasion are important risk factors in aggressive SCC in solid organ transplant recipients. |
| Databáze: | OpenAIRE |
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