Improvement of Cardiac Function after Granulocyte-colony Stimulating Factor-mobilized Peripheral Blood Mononuclear Cell Implantation in a Patient with Non-ischemic Dilated Cardiomyopathy Associated with Thromboangiitis Obliterans
| Autor: | Akio Ishida, Megumi Miyagi, Koichiro Okumura, Tomomasa Kamiyama, Tetsuya Ishiki, Ayano Kakihana, Shuichi Takishita, Yusuke Ohya |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Cardiomyopathy Dilated Male Cardiac function curve thromboangiitis obliterans medicine.medical_specialty Heart disease ^<123>I-metaiodobenzylguanidine Cardiomyopathy Blood Component Transfusion G-CSF Peripheral blood mononuclear cell Internal medicine Granulocyte Colony-Stimulating Factor Natriuretic Peptide Brain Internal Medicine medicine Humans business.industry peripheral blood mononuclear cell implantation Heart Stroke Volume Dilated cardiomyopathy General Medicine Limb Salvage medicine.disease Granulocyte colony-stimulating factor dilated cardiomyopathy medicine.anatomical_structure Ventricle Leukocytes Mononuclear Cardiology Complication business |
| Zdroj: | Internal Medicine. 48(12):1003-1007 |
| ISSN: | 1349-7235 |
| Popis: | Cardiac involvement is a rare complication with thromboangiitis obliterans (TAO). We report a 29-year-old man with TAO accompanied with non-ischemic dilated cardiomyopathy. He had no history of heart disease, but echocardiogram demonstrated diffuse hypokinesis and dilated left ventricle. Coronary angiography revealed no organic stenotic lesion. For limb salvage, he was treated with granulocyte-colony stimulating factor (G-CSF)-mobilized peripheral blood mononuclear cell (PBMNC) implantation on his right leg. Not only ischemic leg symptoms, but also plasma level of BNP and ^I-metaiodobenzylguanidine scintigraphic parameters improved after 24 weeks. G-CSF-mobilized PBMNC implantation could be an effective approach to treating non-ischemic cardiomyopathy. 論文 |
| Databáze: | OpenAIRE |
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