Nonaggressive Versus Aggressive Intravenous Fluid Therapy in Acute Pancreatitis With More Than 24 Hours From Disease Onset: A Randomized Controlled Trial
| Autor: | Héctor J. Maldonado-Garza, Jesus E. Cuellar-Monterrubio, Omar D. Borjas-Almaguer, Emmanuel I. Gonzalez-Moreno, José A. González-González, Roberto Monreal-Robles, Diego Garcia-Compean, José Luis Herrera-Elizondo |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Disease onset Necrosis Ringer's Lactate Time Factors Endocrinology Diabetes and Metabolism Contrast Media law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Intravenous fluid Bolus (medicine) Randomized controlled trial law Internal Medicine medicine Humans Hepatology business.industry Pancreatitis Acute Necrotizing Acute kidney injury Acute Kidney Injury Length of Stay Middle Aged medicine.disease Respiration Disorders Systemic Inflammatory Response Syndrome Systemic inflammatory response syndrome Pancreatitis 030220 oncology & carcinogenesis Anesthesia Acute pancreatitis Fluid Therapy 030211 gastroenterology & hepatology Administration Intravenous Female medicine.symptom business Tomography X-Ray Computed |
| Zdroj: | Pancreas. 49(4) |
| ISSN: | 1536-4828 |
| Popis: | OBJECTIVE This study aimed to compare a "nonaggressive" hydration versus an "aggressive" hydration using Hartmann's solution in patients with acute pancreatitis (AP) with more than 24 hours from disease onset. METHODS We included 88 patients with AP with more than 24 hours from disease onset, and were randomized into 2 groups. Group I (n = 45) received a nonaggressive hydration (Hartmann's solution at 1.5 mL kg h for the first 24 hours and 30 mL kg during the next 24 hours), and group II (n = 43) received an aggressive hydration (bolus of Hartmann's solution 20 mL kg, followed by an infusion of 3 mL kg h for the first 24 hours and then 30 mL kg for the next 24 hours). RESULTS The mean volume of fluid administered was greater in group II (P < 0.001). We did not find differences when comparing both groups in reference to persistent systemic inflammatory response syndrome (P = 0.528), pancreatic necrosis (P = 0.710), respiratory complications (P = 0.999), acute kidney injury (P = 0.714), or length of hospital stay (P = 0.892). CONCLUSIONS Our study suggests that the clinical evolution of patients with AP with more than 24 hours from disease onset is similar using an aggressive or nonaggressive hydration. |
| Databáze: | OpenAIRE |
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