Three dimensional mapping of strontium in bone by dual energy K-edge subtraction imaging
| Autor: | Brian Bewer, M.J.M. Duke, David M. L. Cooper, Yuchin Wu, Michael R. Doschak, Yasmin Carter, Arash Panahifar, W Zhouping, H M Britz, L D Chapman |
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| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Osteoporosis chemistry.chemical_element Rats Sprague-Dawley Imaging Three-Dimensional medicine Animals Humans Radiology Nuclear Medicine and imaging Bone mineral Strontium Radiological and Ultrasound Technology Dual energy Chemistry Phantoms Imaging Subtraction medicine.disease Spine Rats Fluorescent labelling K-edge Subtraction Technique Female Bone adaptation Synchrotrons Biomedical engineering |
| Zdroj: | Physics in medicine and biology. 57(18) |
| ISSN: | 1361-6560 |
| Popis: | The bones of many terrestrial vertebrates, including humans, are continually altered through an internal process of turnover known as remodeling. This process plays a central role in bone adaptation and disease. The uptake of fluorescent tetracyclines within bone mineral is widely exploited as a means of tracking new tissue formation. While investigation of bone microarchitecture has undergone a dimensional shift from 2D to 3D in recent years, we lack a 3D equivalent to fluorescent labeling. In the current study we demonstrate the ability of synchrotron radiation dual energy K-edge subtraction (KES) imaging to map the 3D distribution of elemental strontium within rat vertebral samples. This approach has great potential for ex vivo analysis of preclinical models and human tissue samples. KES also represents a powerful tool for investigating the pharmokinetics of strontium-based drugs recently approved in many countries around the globe for the treatment of osteoporosis. |
| Databáze: | OpenAIRE |
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