Sex differences in the renal changes elicited by angiotensin II blockade during the nephrogenic period
| Autor: | F. J. Salazar, F. Javier Salazar, Analia S. Loria, Fara Saez, M. Teresa Castells, Virginia Reverte, Adelina Zuasti |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Kidney Glomerulus Renal function Hemodynamics Tetrazoles Blood Pressure Nephron Kidney Rats Sprague-Dawley Internal medicine Renin–angiotensin system Internal Medicine medicine Albuminuria Animals Sex Characteristics business.industry Angiotensin II Imidazoles Rats Blood pressure Endocrinology medicine.anatomical_structure Animals Newborn Renal physiology Female medicine.symptom business Angiotensin II Type 1 Receptor Blockers Glomerular Filtration Rate |
| Zdroj: | Hypertension (Dallas, Tex. : 1979). 49(6) |
| ISSN: | 1524-4563 |
| Popis: | The renin–angiotensin system plays an important role in renal development. However, it is unknown whether reduction in angiotensin II effects during the nephrogenic period leads to different renal alterations in males and females during the adult age. The aim of this study was to evaluate whether the role of angiotensin II on renal development is sex dependent and whether there are sex differences in blood pressure, renal hemodynamics, and severity of renal damage during adult life when nephrogenesis is altered by blocking angiotensin II effects. Newborn Sprague–Dawley rats were treated with an angiotensin II type 1 receptor antagonist (L-158.809; 7 mg/kg per day) during the first 2 weeks of life. At 3 months of age, changes in blood pressure, albuminuria, and renal hemodynamics were assessed, and stereological and histopathologic studies were performed. Blood pressure increased (127±0.5 versus 115±0.7 mm Hg in control rats; P P P P P P |
| Databáze: | OpenAIRE |
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