| Popis: |
Background: Abnormalities of striatal structure and function have been considered a core feature of psychosis, especially schizophrenia. Empirical findings from resting-state functional connectivity of subdivisions of the striatum have shown that the ventral and dorsal section of the striatum are connected with the cerebral cortex with different patterns (Di Martino et al, 2008). Studies have also investigated functional connectivity of the ventral and dorsal striatal regions of patients with schizophrenia, first-degree relatives, and high-risk populations. A hypothesis of “dorsal-to-ventral gradient of hypo- to hyper-connectivity with the prefrontal cortex” has been postulated for schizophrenia spectrum disorders (Fornito et al, 2013). Because antipsychotic drug treatment could alter striatal resting-state functional connectivity in patients with schizophrenia (Sarpal et al, 2016), the effect of antipsychotic medications needs to be carefully considered in studies examining striatal functional connectivity. |
