Inactivation of cathepsin D by dithiophosgene and by 2,2-dichloro-1,3-dithiacyclobutanone
| Autor: | Emmanuel T. Rakitzis, T B Malliopoulou |
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| Rok vydání: | 1976 |
| Předmět: |
Time Factors
Chemistry organic chemicals Cathepsin D Spleen Cell Biology Sulfides Cathepsins Biochemistry Molecular biology Butanones Hydrolysis medicine.anatomical_structure Cathepsin O Dithiophosgene Heterocyclic Compounds Cathepsin H medicine Animals heterocyclic compounds Cattle Phosgene Molecular Biology Research Article |
| Zdroj: | Biochemical Journal. 153:737-739 |
| ISSN: | 0264-6021 |
| DOI: | 10.1042/bj1530737 |
| Popis: | Cathepsin D, purified from bovine spleen, is inactivated by the unstable inhibitors dithiophosgene and 2,2-dichloro-1,3-dithiacyclobutanone. Inhibition constants are identical for both of the compounds tested: Ki 96.1 μM;k/c0.406. It appears that the active species is 2,2-dichloro-1,3-dithiacyclobutanone, to which dithiophosgene is hydrolysed before cathepsin D inactivation. |
| Databáze: | OpenAIRE |
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