Outbreak of multiresistant Acinetobacter baumannii in a polyvalent intensive care unit: clinical, epidemiological analysis and PFGE-printing evolution
| Autor: | C. González-Velasco, A. Córdoba-López, P. Villalón-Panzano, S. Valdezate-Ramos, Juan Antonio Sáez-Nieto, J. Monterrubio-Villar |
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| Rok vydání: | 2009 |
| Předmět: |
Acinetobacter baumannii
Adult Microbiology (medical) Genotype Microbial Sensitivity Tests Biology Disease Outbreaks Microbiology law.invention law Drug Resistance Multiple Bacterial Ampicillin medicine Pulsed-field gel electrophoresis Cluster Analysis Humans APACHE Cross Infection Infection Control APACHE II Outbreak General Medicine Sulbactam biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Survival Analysis Intensive care unit Anti-Bacterial Agents Electrophoresis Gel Pulsed-Field Intensive Care Units Infectious Diseases Colistin Acinetobacter Infections medicine.drug |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 28:1281-1284 |
| ISSN: | 1435-4373 0934-9723 |
| Popis: | An outbreak of multidrug-resistant Acinetobacter baumannii (MRAB) occurred over the course of a 27-week period in our adult polyvalent intensive care unit (ICU). Twenty-one patients were affected, and 72 strains were identified from different clinical samples. The strains were resistant to all antibiotics except for colistin and ampicillin/sulbactam. Forty-nine MRAB strains collected from 18 patients were analysed by pulsed-field gel electrophoresis (PFGE). This analysis revealed four highly-related PFGE types (genetic similarity index >90%) termed 1, 2, 3 and 4, that were isolated in 13, seven, one, and three patients, respectively. A single PFGE type was identified from five of ten patients with successive isolation of MRAB; in the other five patients, two or three PFGE types were detected. This suggested phased evolution of PFGE types 2, 3 and 4 from PFGE type 1. Global mortality was high (13 patients; 62%). Non-survivors had higher APACHE II scores than survivors on the date that MRAB was isolated (OR = 1.57; 95% CI [1.02, 2.44]). The outbreak was controlled after implementation of an extensive infection control program. |
| Databáze: | OpenAIRE |
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