Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases
| Autor: | Md. Abdul Alim Al-Bari |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Endosome viruses 030106 microbiology Human immunodeficiency virus (HIV) Reviews Review Biology medicine.disease_cause Dengue fever 03 medical and health sciences Human health antiviral actions Chloroquine medicine Chloroquine analogs General Pharmacology Toxicology and Pharmaceutics endosomal pH and viral replication Influenza a medicine.disease Virology 030104 developmental biology Neurology Immunology Severe acute respiratory syndrome coronavirus Malaria medicine.drug |
| Zdroj: | Pharmacology Research & Perspectives |
| ISSN: | 2052-1707 |
| DOI: | 10.1002/prp2.293 |
| Popis: | Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and other viruses pose a significant threat to human health. Majority of these viruses are responsible for the outbreaks of pathogenic lethal infections. To date, there are no effective therapeutic strategies available for the prophylaxis and treatment of these infections. Chloroquine analogs have been used for decades as the primary and most successful drugs against malaria. Concomitant with the emergence of chloroquine‐resistant Plasmodium strains and a subsequent decrease in the use as antimalarial drugs, other applications of the analogs have been investigated. Since the analogs have interesting biochemical properties, these drugs are found to be effective against a wide variety of viral infections. As antiviral action, the analogs have been shown to inhibit acidification of endosome during the events of replication and infection. Moreover, immunomodulatory effects of analogs have been beneficial to patients with severe inflammatory complications of several viral diseases. Interestingly, one of the successful targeting strategies is the inhibition of HIV replication by the analogs in vitro which are being tested in several clinical trials. This review focuses on the potentialities of chloroquine analogs for the treatment of endosomal low pH dependent emerging viral diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |