Alkaline phosphatases and steroid receptors in human breast cancer
| Autor: | Massimo Quercioli, G. Cardona, Luigi Cataliotti, Paola Tozzi, Gianni Messeri |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Mammary gland Phosphatase Estrogen receptor Breast Neoplasms Biology Biochemistry Dephosphorylation Endocrinology Internal medicine Biomarkers Tumor medicine Humans Receptor Molecular Biology Mastectomy Cancer Cell Biology Alkaline Phosphatase medicine.disease medicine.anatomical_structure Receptors Estrogen Estrogen Molecular Medicine Alkaline phosphatase Female Menopause Receptors Progesterone |
| Zdroj: | The Journal of Steroid Biochemistry and Molecular Biology. 37:269-271 |
| ISSN: | 0960-0760 |
| Popis: | Estrogen receptors (ER), progesterone receptors (PR) and alkaline phosphatases (AP) were measured in 150 tumors from patients who underwent mastectomy for primary breast cancer. The percentage of ER positive samples was inversely related to the AP activity ranging from 88.9% in low activity samples (less than 30 U/mg prot.) down to 30.6% in the high activity ones (greater than 400 U/mg prot.). When considering only ER positive samples, the ER content was inversely related to the AP activity. This could not be demonstrated for PR. Therefore, the authors suggest the hypothesis that in human breast cancer, the AP may play a role in the dephosphorylation of the ER molecule and in the consequent modulation of its binding capability. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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