Inaccurate haemoglobin estimation in Waldenstrom's macroglobulinaemia: unusual reaction with monomeric IgM paraprotein
| Autor: | A. G. Prentice, R. J. Boon, J. A. Copplestone, R. J. D. Bishop, M. J. Goodrick |
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| Rok vydání: | 1993 |
| Předmět: |
Pathology
medicine.medical_specialty biology business.industry Diagnostico diferencial Blood count Waldenstrom macroglobulinemia Critical limit General Medicine medicine.disease Gastroenterology Pathology and Forensic Medicine Mean cell haemoglobin concentration Immunoglobulin M hemic and lymphatic diseases Internal medicine medicine biology.protein Monomeric IgM Hemoglobin business Research Article |
| Zdroj: | Journal of Clinical Pathology. 46:1138-1139 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.46.12.1138 |
| Popis: | Automated blood counts from a patient with Waldenström's macroglobulinaemia repeatedly failed critical limit standards set for mean cell haemoglobin concentration and mean cell haemoglobin. Haemoglobin estimation was higher than that suggested by clinical examination, symptoms, and the spun haematocrit. This was found to be due to an interaction between the Coulter lysing agent and monomeric IgM paraprotein in the patient's plasma, creating a precipitate which was optically dense at 525 nm. |
| Databáze: | OpenAIRE |
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