Phylogeography and epidemiological history of West Nile virus genotype 1a in Europe and the Mediterranean basin
| Autor: | Flavia Bernini, Alessandra Lo Presti, Giovanni Rezza, Erika Ebranati, Massimo Ciccozzi, Gianguglielmo Zehender, Mauro Delogu, Massimo Galli |
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| Přispěvatelé: | G. Zehender, E. Ebranati, F. Bernini, A.Lo Presti, G. Rezza, M.Delogu, M. Galli, M. Ciccozzi |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Microbiology (medical)
Mediterranean climate WNV 2008/2009 ITALIAN EPIDEMIC Genotype Biology Microbiology Mediterranean Basin Monophyly Genetics medicine Humans Clade Molecular Biology Phylogeny Ecology Evolution Behavior and Systematics Likelihood Functions BAYESIAN PHYLOGEOGRAPHY Mediterranean Region Ecology Zoonosis WEST NILE VIRUS GENOTYPE 1A Outbreak Bayes Theorem History 20th Century medicine.disease SPATIO TEMPORAL PHYLODYNAMICS Europe Phylogeography Infectious Diseases Viral phylodynamics MIGRATORY BIRDS West Nile virus West Nile Fever |
| Popis: | Aim of this study was to reconstruct the temporal and spatial phylodynamics of WNV-1a, the genotype to which the majority of European/Mediterranean viral strains belongs, by using sequences retrieved from public databases. WNV-1a isolates segregated into two major clades: the recent West Mediterranean sequences formed a single monophyletic group within clade A. Clade B included sequences from East Mediterranean and America. Phylogeographic analysis suggested that WNV-1a probably originated in sub-Saharan Africa in the early XXth century, and then spread northwards since the late 1970s, via two routes: one crossing Eastern Mediterranean and the other the Western Mediterranean countries. Our data suggest that the circulation of the virus in a given geographical area usually precedes the onset of the outbreak by one year or more, and underline the importance of the spatial–temporal phylodynamics reconstruction in clarifying the recent epidemiology and in setting up an efficient surveillance system for emerging/reemerging zoonosis. |
| Databáze: | OpenAIRE |
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