Genomic reassortment of influenza A virus in North American swine, 1998–2011
Autor: | Xudong Lin, David E. Wentworth, Timothy B. Stockwell, Aaron Schwartzbard, Susan E. Detmer, Yi Tan, Rebecca A. Halpin, Martha I. Nelson, Amy L. Vincent, Edward C. Holmes, Marie Gramer |
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Rok vydání: | 2012 |
Předmět: |
Time Factors
viruses Sus scrofa Reassortment Hemagglutinin Glycoproteins Influenza Virus Genome Viral medicine.disease_cause H5N1 genetic structure Evolution Molecular Virology Reassortant Viruses Evolution of influenza Influenza A virus medicine Animals Humans Phylogeny Genetics biology Animal Antigenic shift Viral phylodynamics North America biology.protein Neuraminidase |
Zdroj: | Journal of General Virology. 93:2584-2589 |
ISSN: | 1465-2099 0022-1317 |
Popis: | Revealing the frequency and determinants of reassortment among RNA genome segments is fundamental to understanding basic aspects of the biology and evolution of the influenza virus. To estimate the extent of genomic reassortment in influenza viruses circulating in North American swine, we performed a phylogenetic analysis of 139 whole-genome viral sequences sampled during 1998–2011 and representing seven antigenically distinct viral lineages. The highest amounts of reassortment were detected between the H3 and the internal gene segments (PB2, PB1, PA, NP, M and NS), while the lowest reassortment frequencies were observed among the H1γ, H1pdm and neuraminidase segments, particularly N1. Less reassortment was observed among specific haemagglutinin–neuraminidase combinations that were more prevalent in swine, suggesting that some genome constellations may be evolutionarily more stable. |
Databáze: | OpenAIRE |
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