Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression
| Autor: | Alexander T. Bean, Sama Adnan, David I. Watkins, David B. Allison, Chungwon Chung, Wonhee Lee, Otto O. Yang, Anna K. Jonas, Nancy A. Wilson, John T. Loffredo, Akihiko Hoji, Eva G. Rakasz, Sean P. Spencer, Jonah B. Sacha, Benjamin J. Burwitz, Jeffrey D. Lifson, Thomas C. Friedrich, Jason J. Stephany |
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| Rok vydání: | 2007 |
| Předmět: |
CD4-Positive T-Lymphocytes
Gene Expression Regulation Viral Time Factors Viral protein T cell viruses Virus Integration Immunology Epitopes T-Lymphocyte Gene Products gag Biology CD8-Positive T-Lymphocytes medicine.disease_cause CCL5 Epitope Article Interleukin 21 MHC class I medicine Immunology and Allergy Cytotoxic T cell Animals AIDS Vaccines Acquired Immunodeficiency Syndrome Histocompatibility Antigens Class I virus diseases Virology Macaca mulatta medicine.anatomical_structure biology.protein HIV-1 Simian Immunodeficiency Virus CD8 |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 178(5) |
| ISSN: | 0022-1767 |
| Popis: | CD8+ T cells are a key focus of vaccine development efforts for HIV. However, there is no clear consensus as to which of the nine HIV proteins should be used for vaccination. The early proteins Tat, Rev, and Nef may be better CD8+ T cell targets than the late-expressed structural proteins Gag, Pol, and Env. In this study, we show that Gag-specific CD8+ T cells recognize infected CD4+ T lymphocytes as early as 2 h postinfection, before proviral DNA integration, viral protein synthesis, and Nef-mediated MHC class I down-regulation. Additionally, the number of Gag epitopes recognized by CD8+ T cells was significantly associated with lower viremia (p = 0.0017) in SIV-infected rhesus macaques. These results suggest that HIV vaccines should focus CD8+ T cell responses on Gag. |
| Databáze: | OpenAIRE |
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