Bioengineering Silicon Quantum Dot Theranostics using a Network Analysis of Metabolomic and Proteomic Data in Cardiac Ischemia
| Autor: | Nikolas Kasabov, Paras N. Prasad, Folarin Erogbogbo, Patrick Gladding, Michelle Jamieson, Seif El Jack, Dariusz Korcyk, Banu Gopalan, Katie Smart, Mark T. Swihart, Mark Webster, Stefan Schliebs, Raphael Hu, Mia Jüllig, Ralph A.H. Stewart, Katherine Bakeev, Linda Liang, Silas G. Villas-Boas, Irene Zeng, Jasmine L. May |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
theranostics
Silicon Proteome medicine.medical_treatment Myocardial Ischemia Medicine (miscellaneous) Bioengineering Bioinformatics Gas Chromatography-Mass Spectrometry Plasma Metabolomics Tandem Mass Spectrometry Quantum Dots medicine Humans Myocardial infarction Biomarker discovery Pharmacology Toxicology and Pharmaceutics (miscellaneous) Coronary sinus Chemistry Percutaneous coronary intervention silicon quantum dots medicine.disease metabolomics cardiac ischemia Coronary occlusion Metabolome Ischemic preconditioning myocardial infarction Reperfusion injury Biomarkers Research Paper Chromatography Liquid |
| Zdroj: | Theranostics Scopus-Elsevier |
| ISSN: | 1838-7640 |
| Popis: | Metabolomic profiling is ideally suited for the analysis of cardiac metabolism in healthy and diseased states. Here, we show that systematic discovery of biomarkers of ischemic preconditioning using metabolomics can be translated to potential nanotheranostics. Thirty-three patients underwent percutaneous coronary intervention (PCI) after myocardial infarction. Blood was sampled from catheters in the coronary sinus, aorta and femoral vein before coronary occlusion and 20 minutes after one minute of coronary occlusion. Plasma was analysed using GC-MS metabolomics and iTRAQ LC-MS/MS proteomics. Proteins and metabolites were mapped into the Metacore network database (GeneGo, MI, USA) to establish functional relevance. Expression of 13 proteins was significantly different (p |
| Databáze: | OpenAIRE |
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