Increased whitening efficacy and reduced cytotoxicity are achieved by the chemical activation of a highly concentrated hydrogen peroxide bleaching gel
| Autor: | Ester Alves Ferreira Bordini, Carlos Alberto de Souza Costa, Fernanda Gonçalves Basso, Natália Marcomini, Josimeri Hebling, Carla Caroline de Oliveira Duque, Diana Gabriela Soares, Uxua Ortecho Zuta |
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| Přispěvatelé: | Universidade de São Paulo (USP), Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2019 |
| Předmět: |
Time Factors
Cell Survival Cytotoxicity Color medicine.disease_cause Statistics Nonparametric 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Chlorides Reference Values Dentin medicine Tooth Bleaching MTT assay Viability assay Ferrous Compounds Hydrogen peroxide Tooth Bleaching Agents General Dentistry Cells Cultured Dental Pulp Peroxidase Analysis of Variance biology Odontoblasts Chemistry Reproducibility of Results 030206 dentistry Hydrogen Peroxide ODONTOBLASTO Catalase lcsh:RK1-715 Dental pulp medicine.anatomical_structure Manganese Compounds lcsh:Dentistry Toxicity biology.protein Tooth bleaching Oxidative stress Nuclear chemistry |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Journal of Applied Oral Science v.27 2019 Journal of applied oral science Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Journal of Applied Oral Science, Volume: 27, Article number: e20180453, Published: 12 AUG 2019 Journal of Applied Oral Science, Vol 27 |
| ISSN: | 1678-7757 |
| Popis: | Made available in DSpace on 2019-10-06T16:44:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-08-12. Added 1 bitstream(s) on 2019-10-09T18:35:36Z : No. of bitstreams: 1 S1678-77572019000100467.pdf: 607551 bytes, checksum: 06e948f68ed20d5bb3e85aea92064170 (MD5) OBJECTIVE: This study was designed for the chemical activation of a 35% hydrogen peroxide (H2O2) bleaching gel to increase its whitening effectiveness and reduce its toxicity. METHODOLOGY: First, the bleaching gel - associated or not with ferrous sulfate (FS), manganese chloride (MC), peroxidase (PR), or catalase (CT) - was applied (3x 15 min) to enamel/dentin discs adapted to artificial pulp chambers. Then, odontoblast-like MDPC-23 cells were exposed for 1 h to the extracts (culture medium + components released from the product), for the assessment of viability (MTT assay) and oxidative stress (H2DCFDA). Residual H2O2 and bleaching effectiveness (DE) were also evaluated. Data were analyzed with one-way ANOVA complemented with Tukey's test (n=8. p |
| Databáze: | OpenAIRE |
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