| Autor: |
Lee M. Ellis, Delphine Boulbes, Fan Fan, Madonna McManus, Xia Ling, Rui Wang, Xiang-Cang Ye, Rajat Bhattacharya |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22407992.v1 |
| Popis: |
siRNA mediated knock-down of VEGF in CRC cells (S1); Proliferation of CRC cells is not effected by blocking paracrine/Autocrine VEGF signaling (S2); VEGF depletion in CRC cells affect survival signaling (S3); Validation of VEGFR1 inhibitors (S4); Depletion but not inhibition of VEGFR1 in CRC cells lead to reduced survival signaling (S5); CRC cells have insignificant amounts of secreted VEGFR1 (S6); VEGF and VEGFR1 interact in CRC cells (S7); Localization of VEGF and VEGFR1 in CRC cells (S8); Possible mechanisms of VEGF depletion and it's effects on phosphorylation status of AKT in CRC cells (S9). VEGF depletion effects phosphorylation of multiple RTKs in CRC cells (S10); Overexpression of RTKs can rescue pAKT levels in VEGF depleted CRC cells (S11); Potential mechanism of intracrine VEGF signaling in CRC cells (S12). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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