The Natural Abundance Of L-Canavanine, An Active Anticancer Agent, in Alfalfa, Medicago Sativa (L.)
| Autor: | Palesa Nkomo, Gerald A. Rosenthal |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pharmacology
chemistry.chemical_classification food and beverages Pharmaceutical Science General Medicine Biology Canavalia biology.organism_classification Amino acid chemistry.chemical_compound Complementary and alternative medicine chemistry Abundance (ecology) Drug Discovery Botany Shoot Molecular Medicine Dry matter Cultivar Medicago sativa Canavanine |
| Zdroj: | Pharmaceutical Biology. 38:1-6 |
| ISSN: | 1744-5116 1388-0209 |
| DOI: | 10.1076/1388-0209(200001)3811-bft001 |
| Popis: | L-Canavanine, a potentially toxic antimetabolite of L-arginine that is stored by many leguminous plants, has demonstrative antineoplastic activity against a number of animal-bearing carcinomas and cancer cell lines. This investigation evaluated the natural abundance of this anti-cancer compound in commercially available sprouts, and in ten varieties of the seed of alfalfa, Medicago Sativa (L.). Canavanine abundance in commercially grown sprouts varied according to the source; the young plant stored appreciable canavanine that ranged from 1.3 to 2.4% of the dry matter. Alfalfa seeds were also rich in this nonprotein amino acid as the canavanine content varied from 1.4 to 1.8% of the dry matter. On average, the tested seeds contained 1.54 ± 0.03% canavanine. Alfalfa seed canavanine content was comparable to the levels found in the seeds of representative members of the genus Canavalia , which are amongst the more abundance sources of this antimetabolite. |
| Databáze: | OpenAIRE |
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