Acid-fast bacilli culture positivity and drug resistance in abdominal tuberculosis in Mumbai, India
Autor: | Hrishikesh Samant, Philip Abraham, Siji George, Anand Joshi, Tarun Gupta, Devendra Desai, Camilla Rodrigues |
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Rok vydání: | 2014 |
Předmět: |
Adult
Male medicine.medical_specialty Tuberculosis Adolescent Antitubercular Agents India Microbial Sensitivity Tests Drug resistance Gastroenterology Young Adult fluids and secretions Internal medicine Drug Resistance Bacterial Prevalence Humans Medicine Aged Retrospective Studies biology business.industry Histology Retrospective cohort study Mycobacterium tuberculosis Middle Aged Hepatology bacterial infections and mycoses biology.organism_classification medicine.disease Surgery Löwenstein–Jensen medium Multiple drug resistance Tuberculosis Gastrointestinal Mycobacterium tuberculosis complex Female business |
Zdroj: | Indian Journal of Gastroenterology. 33:414-419 |
ISSN: | 0975-0711 0254-8860 |
Popis: | Culture positivity for Mycobacterium tuberculosis complex (MTB) in abdominal tuberculosis (TB) using Lowenstein Jensen medium and Bactec system varies from 25 % to 36 %. Data on the prevalence of drug resistance in primary abdominal TB is scant. Our aim was to study the acid-fast bacilli (AFB) culture positivity rate in primary abdominal TB using Bactec Mycobacterial Growth Indicator Tubes (MGIT) system and the prevalence of drug resistance in these patients. Records of patients with abdominal TB (diagnosed on clinical features, endoscopy, histology, microbiology) seen during the period 2008 to 2013 were retrieved from the Gastroenterology and Microbiology departments. Patients with extra-abdominal TB (five pulmonary, two nodal), adnexal (one), and HIV (one) were excluded from analysis. Of 61 patients, 31 (50.8 %) had a positive AFB culture. In the 30 culture-negative patients, histology showed non-caseating granulomas in 25 patients. Drug sensitivity pattern was analyzed in 18 patients; resistance was detected in eight (14.3 % of all patients and 44.4 % of patients in whom drug sensitivity was done) including three (5.4 % of all subjects and 16.6 % in whom drug sensitivity was available) who were multidrug-resistant. The rate of AFB culture positivity in primary abdominal TB was 50.8 % using Bactec MGIT. Likelihood of drug resistance was seen in 14.3 %, of whom 5.4 % were multidrug-resistant. |
Databáze: | OpenAIRE |
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