In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery
| Autor: | Anders Björkbom, Andreas Hugerth, Katrin Walter, David Janzén, S. F. Nunes, Stanko Skrtic, Bertil Abrahamsson, Christel A. S. Bergström, Werner Weitschies, Julius Krause, Said Harun, Staffan Berg, Malin Antonsson, Natalie Van Zuydam, Nigel Davies, Andreas Granfeldt |
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| Rok vydání: | 2021 |
| Předmět: |
Cmax
Administration Oral Biological Availability Pharmaceutical Science Octreotide Capsules 02 engineering and technology Absorption (skin) Pharmacology 030226 pharmacology & pharmacy Dosage form Intestinal absorption 03 medical and health sciences Dogs 0302 clinical medicine Pharmacokinetics In vivo medicine Animals Chemistry 021001 nanoscience & nanotechnology Bioavailability Printing Three-Dimensional Tablets Enteric-Coated Peptides 0210 nano-technology medicine.drug |
| Zdroj: | Journal of Pharmaceutical Sciences. 110:228-238 |
| ISSN: | 0022-3549 |
| Popis: | In this study a 3D printed capsule designed to break from the physiological pressures in the antropyloric region was evaluated for its ability to deliver the synthetic octapeptide octreotide in beagle dogs when co-formulated with the permeation enhancer sodium caprate. The pressure sensitive capsules were compared to traditional enteric coated hard gelatin capsules and enteric coated tablets. Paracetamol, which is completely absorbed in dogs, was included in the formulations and used as an absorption marker to give information about the in vivo performance of the dosage forms. The pressure sensitive capsules released drug in 50% of the dogs. In the cases where drug was released, there was no difference in octreotide bioavailability or Cmax compared to the enteric coated dosage forms. When comparing all dosage forms, a correlation was seen between paracetamol Cmax and octreotide bioavailability, suggesting that a high drug release rate may be beneficial for peptide absorption when delivered together with sodium caprate. |
| Databáze: | OpenAIRE |
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