Sex specific effect of alcohol on hepatic plasmacytoid dendritic cells
| Autor: | Tori Klenk, Khaled Alharshawi, Costica Aloman, Holger Fey, Miran Kim, Alyx Vogle |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Alcoholic liver disease CCR2 Alcohol Drinking Receptors CCR2 Immunology Population Article 03 medical and health sciences Chemokine receptor Chimera (genetics) Mice 0302 clinical medicine Immune system Sex Factors medicine Immunology and Allergy Animals education Liver Diseases Alcoholic Pharmacology Liver injury education.field_of_study Ethanol business.industry hemic and immune systems Dendritic Cells medicine.disease Mice Inbred C57BL Alcoholism 030104 developmental biology medicine.anatomical_structure Liver 030220 oncology & carcinogenesis Models Animal Hepatocytes Female Bone marrow business |
| Zdroj: | Int Immunopharmacol |
| ISSN: | 1878-1705 |
| Popis: | Alcoholic liver disease includes a spectrum of clinical and histological entities. They result from the combined direct effect of alcohol and its metabolites on immune cells and resident tissue cells. In humans and mice, females are more susceptible to alcoholic liver injury than males. Despite being involved in sex specific differences of immune mediated tissue injury, plasmacytoid dendritic cells (pDCs) have not been thoroughly assessed as a cellular target of alcohol in humans or mice. Therefore, Meadows-Cook diet was used to study alcohol effect on hepatic dendritic cells. Alcohol consumption for 12 weeks increased hepatic pDCs in female mice. The expression of the C-C chemokine receptor type 2 (CCR2) increased in hepatic pDC of alcohol-fed female mice. Bone marrow transplant chimera showed CCR2 dependent bone marrow egress of pDCs. Chronic alcohol exposure has a sex specific effect on hepatic pDCs population that may explain sex differences to alcoholic liver disease. |
| Databáze: | OpenAIRE |
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