Effect of single-dose omeprazole on intragastric acidity and volume during obstetric anaesthesia
| Autor: | R. J. Flynn, K. R. W. Gillon, C. M. Wilson, M. Sampaio, J. Moore |
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| Rok vydání: | 1989 |
| Předmět: |
Pregnancy
medicine.medical_specialty Evening Gastric acidity business.industry medicine.medical_treatment Antisecretory agents Aspiration pneumonia medicine.disease Surgery Obstetric anaesthesia Anesthesiology and Pain Medicine Oral administration Antacid Anesthesia medicine Premedication General anaesthesia Elective caesarean section business Omeprazole medicine.drug |
| Zdroj: | Anaesthesia. 44:559-562 |
| ISSN: | 1365-2044 0003-2409 |
| DOI: | 10.1111/j.1365-2044.1989.tb11441.x |
| Popis: | Various antacid or antisecretory agents are used to reduce the risk to patients of aspiration of gastric contents during general anaesthesia and a trial of the gastric proton pump inhibitor, omeprazole, is reported here. Twenty women admitted for elective Caesarean section under general anaesthesia received a single 80-mg oral omeprazole dose at 2000 hours on the evening before surgery. Intragastric pH and volume were measured immediately after induction of anaesthesia and on completion of surgery. Eighty-five percent of pH measurements at induction and extubation and 80% and 95% of volume measurements at induction and extubation respectively met the defined success criteria (pH greater than or equal to 2.5, volume less than 25 ml). Omeprazole treatment was well tolerated by the women and Apgar scores and subsequent progress of the babies were acceptable. These results indicate that gastric acidity and volume were acceptable in the majority of women after omeprazole treatment, but the interval from drug administration to induction of anaesthesia may have been too long in some cases and resulted in unacceptably low pHs. |
| Databáze: | OpenAIRE |
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