Albumin nanoparticles for the delivery of gabapentin: Preparation, characterization and pharmacodynamic studies
| Autor: | Y. Lavanya, Josephine Leno Jenita, Barnabas Wilson, Muthu Ramasamy, S.R.B. Priyadarshini |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Drug Cyclohexanecarboxylic Acids Gabapentin Drug Compounding media_common.quotation_subject Albumin nanoparticles Polysorbates Pharmaceutical Science Nanoparticle Pharmacology Polyvinyl alcohol chemistry.chemical_compound Seizures Convulsion medicine Animals Free drug Amines Rats Wistar gamma-Aminobutyric Acid media_common Drug Carriers Electroshock Brain Serum Albumin Bovine Disease Models Animal chemistry Pharmacodynamics Nanoparticles Pentylenetetrazole Anticonvulsants medicine.symptom medicine.drug |
| Zdroj: | International Journal of Pharmaceutics. 473:73-79 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/j.ijpharm.2014.05.056 |
| Popis: | The study was aimed to prepare and evaluate gabapentin loaded albumin nanoparticles and to find out their effectiveness in treating epilepsy. Albumin nanoparticles of gabapentin were prepared by pH-coacervation method. The drug was administered into animals as free drug, gabapentin bound with nanoparticles, and gabapentin bound with nanoparticles coated with polysorbate 80. The polysorbate 80 coated nanoparticles increased the gabapentin concentration in the brain about 3 fold in comparison with the free drug. Moreover, the polysorbate 80 coated nanoparticles significantly reduced the duration of all phases of convulsion in both maximal electroshock induced and pentylenetetrazole induced convulsion models in comparison with free drug and drug bound with nanoparticle formulations, which indicates the ability of polysorbate 80 coated nanoparticles to enhance the gabapentin concentration in the brain. |
| Databáze: | OpenAIRE |
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