Cortical and Thalamic Excitation Mediate the Multiphasic Responses of Striatal Cholinergic Interneurons to Motivationally Salient Stimuli
| Autor: | Peter J. Magill, J. P. Bolam, Paul Apicella, Natalie M. Doig, Andrew Sharott |
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| Přispěvatelé: | Department of Pharmacology [Oxford], University of Oxford, Laboratoire de Neurosciences Cognitives [Marseille] (LNC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), University of Oxford [Oxford], Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Interneuron Thalamus Stimulus (physiology) parafascicular nucleus thalamostriatal Midbrain corticostriatal 03 medical and health sciences 0302 clinical medicine Interneurons Parasympathetic Nervous System Basal ganglia medicine tonically active neuron Animals 030304 developmental biology Cerebral Cortex Motivation 0303 health sciences musculoskeletal neural and ocular physiology General Neuroscience Articles Neostriatum medicine.anatomical_structure nervous system Cerebral cortex basal ganglia Excitatory postsynaptic potential Cholinergic [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroscience Journal of Neuroscience, 2014, 34 (8), pp.3101-3117. ⟨10.1523/JNEUROSCI.4627-13.2014⟩ Journal of Neuroscience, Society for Neuroscience, 2014, 34 (8), pp.3101-3117. ⟨10.1523/JNEUROSCI.4627-13.2014⟩ |
| ISSN: | 0270-6474 1529-2401 |
| DOI: | 10.1523/JNEUROSCI.4627-13.2014⟩ |
| Popis: | Cholinergic interneurons are key components of striatal microcircuits. In primates, tonically active neurons (putative cholinergic interneurons) exhibit multiphasic responses to motivationally salient stimuli that mirror those of midbrain dopamine neurons and together these two systems mediate reward-related learning in basal ganglia circuits. Here, we addressed the potential contribution of cortical and thalamic excitatory inputs to the characteristic multiphasic responses of cholinergic interneuronsin vivo. We first recorded and labeled individual cholinergic interneurons in anesthetized rats. Electron microscopic analyses of these labeled neurons demonstrated that an individual interneuron could form synapses with cortical and, more commonly, thalamic afferents. Single-pulse electrical stimulation of ipsilateral frontal cortex led to robust short-latency ( |
| Databáze: | OpenAIRE |
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