Effects of CDP-choline and the combination of CDP-choline and galantamine differ in an animal model of schizophrenia: Development of a selective α7 nicotinic acetylcholine receptor agonist strategy
| Autor: | Nina R. Schooler, Barbara L. Schwartz, John Mastropaolo, Brooke L. Gaskins, Stephen I. Deutsch, Richard B. Rosse, Katrice D. Long |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Agonist Cytidine Diphosphate Choline medicine.drug_class Pharmacology complex mixtures Mice Ganglion type nicotinic receptor Galantamine Animals Medicine Drug Interactions Pharmacology (medical) Receptor Nootropic Agents Biological Psychiatry Analysis of Variance Behavior Animal business.industry medicine.disease carbohydrates (lipids) Disease Models Animal Psychiatry and Mental health Nicotinic agonist nervous system Neurology Schizophrenia NMDA receptor Drug Therapy Combination lipids (amino acids peptides and proteins) Cholinesterase Inhibitors Neurology (clinical) Dizocilpine Maleate Alpha-4 beta-2 nicotinic receptor business Excitatory Amino Acid Antagonists Neuroscience medicine.drug |
| Zdroj: | European Neuropsychopharmacology. 18:147-151 |
| ISSN: | 0924-977X |
| Popis: | The regionally selective reduction of expression of the alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) in schizophrenia underlies impaired sensory inhibition, a possible endophenotype of the disorder. This ligand-gated ion channel receptor has been proposed as a pharmacotherapeutic target in schizophrenia. The current study examined the effect of CDP-choline alone and the combination of CDP-choline and galantamine, administered acutely and once-daily for five consecutive days, in an animal model of NMDA receptor hypofunction that is relevant to schizophrenia. The results support the allosteric modulatory influence of galantamine on CDP-choline; however, individual doses of CDP-choline and galantamine must be carefully titrated in order to achieve optimal levels of alpha7 nAChR "agonism" that may be necessary for the desired therapeutic effect. |
| Databáze: | OpenAIRE |
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