Conditioning to Injection Procedures and Repeated Testing Increase SCH 23390-Induced Catalepsy in Mice
| Autor: | Cibele Cristina Chinen, Roberto Frussa-Filho |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Metoclopramide Mice Inbred Strains Catalepsy Mice chemistry.chemical_compound Dopamine Internal medicine Conditioning Psychological medicine Haloperidol Animals Sensitization Pharmacology SCH-23390 Behavior Animal Dopamine antagonist Benzazepines medicine.disease Disease Models Animal Psychiatry and Mental health Endocrinology medicine.anatomical_structure chemistry Dopamine receptor Dopamine Agonists Dopamine Antagonists 2 3 4 5-Tetrahydro-7 8-dihydroxy-1-phenyl-1H-3-benzazepine Psychology Locomotion medicine.drug |
| Zdroj: | Neuropsychopharmacology. 21:670-678 |
| ISSN: | 0893-133X |
| DOI: | 10.1016/s0893-133x(99)00061-5 |
| Popis: | The cataleptic behavior induced by the dopamine D1 antagonist SCH 23390 (SCH) has proven to be a useful assay for investigating the sensitivity of D1-like dopamine receptor-mediated effects during chronic drug administration. A fundamental flaw in most of these studies may be the involvement of the "repeated measures effect," a behavioral phenomenon well demonstrated for neuroleptic-induced catalepsy but not yet investigated for dopamine D1 antagonists. In this study, mice exposed for various sessions to the bar test presented a strong sensitization to the cataleptic behavior induced by repeated SCH treatment. Conversely, single tested animals exhibited a trend toward decreased catalepsy after repeated SCH treatment, which was in line with the development of a D1-like dopamine receptor supersensitivity suggested by an increase in SKF 38393-induced grooming behavior. Surprisingly, a challenge intraperitoneal saline injection increased the cataleptic behavior of single tested mice after long-term SCH treatment. This "injection-conditioned catalepsy" was also observed after repeated treatment with the dopamine D2 antagonists, haloperidol and metoclopramide. While these findings seem to explain some important contradictory data in the literature, they provide a new and simple animal model of the placebo effect. |
| Databáze: | OpenAIRE |
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