Association between adipose tissue depots and dyslipidemia: The KORA-MRI population-based study
| Autor: | Ricarda von Krüchten, Roberto Lorbeer, Katharina Müller-Peltzer, Susanne Rospleszcz, Corinna Storz, Esther Askani, Charlotte Kulka, Christopher Schuppert, Wolfgang Rathmann, Annette Peters, Fabian Bamberg, Christopher L. Schlett, Blerim Mujaj |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
Nutrition and Dietetics Subcutaneous Fat Intra-Abdominal Fat Middle Aged Magnetic Resonance Imaging Body Mass Index Adipose Tissue adipose tissue total cholesterol LDL-cholesterol HDL-cholesterol triglycerides magnetic resonance imaging population-based cohort Humans Female Aged Dyslipidemias Food Science Hdl-cholesterol Ldl-cholesterol Population-based Cohort Total Cholesterol Triglycerides |
| Zdroj: | Nutrients 14:797 (2022) Nutrients; Volume 14; Issue 4; Pages: 797 |
| Popis: | Obesity increases the risk of cardiovascular diseases (CVD), however, whether adipose tissue relates to dyslipidemia, and consequently to cardiovascular events remains unknown. Thus, we investigated the association of adipose tissue with circulating lipoproteins and triglycerides (TG) in subjects without CVD. 384 participants from the KORA-MRI study (mean age 56.2 ± 9.2 years; 41.9% female) underwent whole-body 3T-MRI. Visceral (VAT) and subcutaneous adipose tissue (SAT) derived from T1-DIXON-sequence using a semi-automatic algorithm. Total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and TG were measured. Linear regression was applied to examine the relationships between adipose tissue, circulating lipoproteins, and TG, adjusting for risk factors. VAT was associated with total cholesterol (per SD increase) (ß = 0.39, p < 0.001). Total adipose tissue (TAT) and VAT were inversely associated with HDL (ß = −0.09, p = 0.009; ß = −0.14, p < 0.001), and positively associated with LDL (ß = 0.32, p < 0.001; ß = 0.37, p < 0.001). All adipose tissues were associated with TG (ß = 0.20, p < 0.001; ß = 0.27, p < 0.001; ß = 0.11, p = 0.004). Stratified analysis by sex and body mass index (BMI) was confirmatory in women and in individuals with BMI < 30. Our results suggest that adipose tissue plays an important role in increasing CVD risk independent of BMI, whereas gender imbalance may be explained by accurate characterization and quantification of adipose tissue. |
| Databáze: | OpenAIRE |
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