Wide-Field Spectral-Domain Optical Coherence Tomography in Patients and Carriers of X-linked Retinoschisis
| Autor: | Potyra R. Aroucha, Fawzi Abukhalil, Ninel Z. Gregori, S. Ranganathan, Byron L. Lam, Giovanni Gregori, Edwin M. Stone, Alexis Morante |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Heterozygote medicine.medical_specialty Visual acuity Adolescent Genotype genetic structures Retinoschisis DNA Mutational Analysis Posterior pole Visual Acuity Nerve fiber layer Article Retina Ophthalmology medicine Humans Prospective Studies Child medicine.diagnostic_test business.industry Fundus photography Middle Aged medicine.disease eye diseases Visual field medicine.anatomical_structure Child Preschool Optic nerve Optometry Female sense organs Visual Fields medicine.symptom business Tomography Optical Coherence |
| Zdroj: | Ophthalmology. 120:169-174 |
| ISSN: | 0161-6420 |
| Popis: | Purpose To evaluate macular and extramacular retinal anatomy in patients and carriers of X-linked retinoschisis (XLRS) using a wide-field spectral-domain optical coherence tomography (SD-OCT) imaging technique. Design Case series. Participants Six XLRS-affected male subjects and 3 XLRS female carriers. Methods The subjects prospectively underwent XLRS DNA genotyping and comprehensive ophthalmic examination, including visual acuity, 30-2 Humphrey visual field, fundus photography, and wide-field SD-OCT, a montage technique to generate SD-OCT images spanning approximately 50 degrees horizontally and 35 degrees vertically of the posterior pole. Main Outcome Measures Distribution and location of schisis cavities. Results Among male subjects affected by XLRS, asymmetric bilateral schisis was seen in all eyes imaged with montage SD-OCT (11 eyes). Wide-field OCT images demonstrated schisis cavities only in the central macula in 6 eyes (55%), throughout the macula extending to the outside of the temporal arcades in 3 eyes (27%), and throughout the macula extending nasal to the optic nerve in 2 eyes (18%). Cystoid spaces accounting for macular splitting were present in the inner nuclear layer (INL) in all 11 eyes and in the outer nuclear layer (ONL) in 4 eyes. A few small cysts were seen parafoveally in the ganglion cell layer (GCL) or nerve fiber layer (NFL) in 4 eyes. Subclinical extramacular schisis spaces were seen (n=5 eyes) within the INL in 1 eye, the ONL in 1 eye, the INL/GCL/NFL in 1 eye, the ONL/GCL/NFL in 1 eye, and the INL/ONL/GCL/NFL in 1 eye. Schisis was rarely seen nasal to the optic nerve (2 eyes). Central/paracentral visual field defects were seen in 9 eyes. Female carriers did not show schisis on examination or OCT. Conclusions Wide-field SD-OCT is a useful tool for evaluating complex retinal anatomy. In patients with XLRS, the foveomacular schisis was seen most frequently in the INL. Subclinical extramacular schisis was seen in 45% of eyes and was equally prevalent in the INL, ONL, and GCL/FNL. The GCL/FNL cystoid spaces were small and seen near the fovea and the arcades only. Carriers were schisis-free. Financial Disclosure(s) The author(s) have no proprietary or commercial interest in any materials discussed in this article. |
| Databáze: | OpenAIRE |
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