Hypofractionated stereotactic radiotherapy for oligometastases in the brain: a single-institution experience
| Autor: | Marcello Marchetti, Luisa Fumagalli, L.C. Bianchi, Chiara Falcone, Lorenzo Brait, Laura Fariselli, Michela De Santis, I. Milanesi |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Recursive partitioning Dermatology Radiosurgery Stereotaxic Techniques Humans Medicine Adverse effect Aged Retrospective Studies Neuroradiology Radiotherapy Brain Neoplasms business.industry Dose fractionation Retrospective cohort study General Medicine Middle Aged Prognosis Surgery Survival Rate Radiation therapy Psychiatry and Mental health Treatment Outcome Stereotaxic technique Disease Progression Female Dose Fractionation Radiation Neurology (clinical) Neurosurgery business |
| Zdroj: | Neurological Sciences. 32:393-399 |
| ISSN: | 1590-3478 1590-1874 |
| DOI: | 10.1007/s10072-010-0473-4 |
| Popis: | The treatment of brain metastases is changing. Many different radiotherapy options are now available and under clinical evaluation. As part of this effort, we retrospectively evaluated the efficacy and toxicity of hypofractionated stereotactic radiotherapy (HSRT) in patients with up to three brain metastases. Sixty-five patients with 81 lesions were treated with hypofractionated radiotherapy. Median dose was 24 Gy in three fractions. Median follow-up was 24.6 months. Actuarial tumour control was 75 and 45% at 9 months and 24 months after treatment, respectively. Median survival time was 7.5 months, and 32% of the patients died from brain tumour progression. Actuarial overall survival was 75% at 3 months and 25% at 12 months. Recursive partitioning analysis class was the only significant prognostic factor. Neoadjuvant whole-brain radiotherapy (in 29 patients) had no impact on survival or local control. Neurological status improved in 42 patients (65%). Adverse events were rare and usually mild. This experience suggests HSRT should be considered as an alternative approach in the treatment of one to three metastatic lesions in selected patients. |
| Databáze: | OpenAIRE |
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