The MHC-haplotype influences primary, but not memory, immune responses to an immunodominant peptide containing T- and B-cell epitopes of the caprine arthritis encephalitis virus Gag protein
| Autor: | Gabriela Obexer-Ruff, André Busato, Shiv Charan, Giuseppe Bertoni, Ernst Peterhans, Hans-Rudolf Vogt, Chiara Nenci, Marie-Luise Zahno, Gianfranco Pancino, Alexandra Fluri |
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| Rok vydání: | 2006 |
| Předmět: |
Arthritis-Encephalitis Virus
Caprine T-Lymphocytes Molecular Sequence Data Gene Products gag Enzyme-Linked Immunosorbent Assay Immunodominance Major histocompatibility complex Protein Structure Secondary Epitope Virus Major Histocompatibility Complex Immune system MHC class I Animals Amino Acid Sequence Caprine arthritis encephalitis virus Immunization Schedule Cell Proliferation B-Lymphocytes General Veterinary General Immunology and Microbiology biology Immunodominant Epitopes Goats Public Health Environmental and Occupational Health Group-specific antigen biology.organism_classification Virology Infectious Diseases Haplotypes Antibody Formation Hemocyanins Immunology biology.protein Molecular Medicine Peptides Immunologic Memory |
| Zdroj: | Vaccine. 24:597-606 |
| ISSN: | 0264-410X |
| Popis: | In this report, we describe a short peptide, containing a T helper- and a B-cell epitope, located in the Gag protein of the caprine arthritis encephalitis virus (CAEV). This T-cell epitope is capable of inducing a robust T-cell proliferative response in vaccinated goats with different genetic backgrounds and to provide help for a strong antibody response to the B-cell epitope, indicating that it may function as a universal antigen-carrier for goat vaccines. The primary immune response of goats homozygous for MHC class I and II genes showed an MHC-dependent partitioning in rapid-high and slow-low responses, whereas the memory immune response was strong in both groups, demonstrating that a vaccine based on this immunodominant T helper epitope is capable to overcome genetic differences. |
| Databáze: | OpenAIRE |
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