Established and emerging therapeutic uses of PDE type 5 inhibitors in cardiovascular disease
| Autor: | David J. Webb, Tariq E. Farrah, Neeraj Dhaun, Nikolaos Tzoumas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Sildenafil Disease Review Article Bioinformatics TARGETING THE NITRIC OXIDE (NO)‐cGMP PATHWAY: THERAPEUTIC OPPORTUNITIES IN THE 21ST CENTURY Sildenafil Citrate Tadalafil Angina 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Erectile Dysfunction Diabetes mellitus medicine Humans Pharmacology business.industry Phosphodiesterase 5 Inhibitors medicine.disease 030104 developmental biology Erectile dysfunction chemistry Vardenafil Cardiovascular Diseases Hypertension business 030217 neurology & neurosurgery medicine.drug Kidney disease |
| Zdroj: | British Journal of Pharmacology |
| ISSN: | 1476-5381 0007-1188 |
| Popis: | PDE type 5 inhibitors (PDE5Is), such as sildenafil, tadalafil and vardenafil, are a class of drugs used to prolong the physiological effects of NO/cGMP signalling in tissues through the inhibition of cGMP degradation. Although these agents were originally developed for the treatment of hypertension and angina, unanticipated side effects led to advances in the treatment of erectile dysfunction and, later, pulmonary arterial hypertension. In the last decade, accumulating evidence suggests that PDE5Is may confer a wider range of clinical benefits than was previously recognised. This has led to a broader interest in the cardiovascular therapeutic potential of PDE5Is, in conditions such as hypertension, myocardial infarction, stroke, peripheral arterial disease, chronic kidney disease and diabetes mellitus. Here, we review the pharmacological properties and established licensed uses of this class of drug, along with emerging therapeutic developments and possible future indications. |
| Databáze: | OpenAIRE |
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