Artificial sweeteners impair endothelial vascular reactivity: Preliminary results in rodents

Autor: Guillaume Walther, S. Risdon, Grégory Meyer, Matthieu Roustit, Alexandra Marziou, Catherine Riva
Přispěvatelé: EA4278 Laboratoire de Pharm-Ecologie Cardiovasculaire (LaPEC), Avignon Université (AU), Roswell Park Cancer Institute [Buffalo], Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Sucrose
Sucralose
Acceptable daily intake
Endothelium
Endocrinology
Diabetes and Metabolism
Population
Subcutaneous Fat
Thiazines
Acesulfame potassium
Medicine (miscellaneous)
Adipose tissue
Physiology
030209 endocrinology & metabolism
Disease
030204 cardiovascular system & hematology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
medicine
[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Animals
Rats
Wistar
Endothelial dysfunction
education
Aorta
ComputingMilieux_MISCELLANEOUS
Adiposity
2. Zero hunger
education.field_of_study
Nutrition and Dietetics
Dose-Response Relationship
Drug
business.industry
medicine.disease
3. Good health
Vasodilation
medicine.anatomical_structure
chemistry
Sweetening Agents
Endothelium
Vascular
Cardiology and Cardiovascular Medicine
business
Preliminary Data
Zdroj: Nutrition, Metabolism and Cardiovascular Diseases
Nutrition, Metabolism and Cardiovascular Diseases, Elsevier, 2020, 30 (5), pp.843-846. ⟨10.1016/j.numecd.2020.01.014⟩
ISSN: 0939-4753
DOI: 10.1016/j.numecd.2020.01.014⟩
Popis: Background and aims Prospective epidemiological studies highlighted recently the link between artificial sweeteners (AS) consumption and the risk of developing cardiometabolic diseases. However, underlying mechanisms remain unknown. Thus, the aim of this preliminary study was to characterize, in a healthy rat population, the effect of chronic AS consumption on body composition and vascular function, an early marker for cardiovascular disease. Methods and results Healthy Wistar rats followed a 10-week standard diet including the consumption of water sweetened or not with a sucralose/acesulfame potassium solution at different concentrations: for moderate consumption at 1 and 2 mg.kg−1.day−1, respectively or high intake at 15 and 15 mg.kg−1.day−1 for both molecules (acceptable daily intake). Body fat composition has been evaluated and ex vivo aortic vasomotor function has been investigated with a pharmacological approach. Conclusion Both groups of AS-treated rats showed a significant increase in subcutaneous and perirenal adipose tissue mass storage, without changes in total body mass. However, rats that have consumed AS at Acceptable Daily Intake (ADI) concentration revealed a significant vascular endothelial dysfunction compared to other groups. These results are interesting because they will help to better explain the observed increase in cardiometabolic risk.
Databáze: OpenAIRE
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